Three shows come to mind for me
1- GNR/Metallica/Faith No More - friend was going and invited me but since we both worked at the same place at the time and it being a small business I wasnt able to get the time off to go
2- Guns N Roses - years before Chinese Democracy came out I had a ticket but could not get anybody to cover my shift or switch with me for work. That irked me!
3- Cranberries I had bought tickets to see them, and then I had to have emergency gall bladder surgery and I was in no shape to go to a show especially when getting out of bed to sit on the couch was a feat in itself